Serum Antibodies against Genitourinary Infectious Agents in Prostate Cancer and Benign Prostate Hyperplasia Patients: A Case-Control Study

0356343 - ÚI 2011 RIV GB eng J - Journal Article
Hrbáček, J. - Urban, M. - Hamšíková, E. - Tachezy, R. - Eisenbruk, V. - Brabec, Marek - Heráček, J.
Serum Antibodies against Genitourinary Infectious Agents in Prostate Cancer and Benign Prostate Hyperplasia Patients: A Case-Control Study.
Bmc Cancer. Roč. 11, Art.no. 53 (2011), s. 1-10. E-ISSN 1471-2407
Institutional research plan: CEZ:AV0Z10300504
Keywords : serum antibodies * prostate cancer * case-control study * logistic regression, calibration
Subject RIV: BB - Applied Statistics, Operational Research
Impact factor: 3.011, year: 2011

Infection plays a role in the pathogenesis of many human malignancies. Whether prostate cancer (PCa) - an important health issue in the aging male population in the Western world - belongs to these conditions has been a matter of research since the 1970s. Persistent serum antibodies are a proof of present or past infection. The aim of this study was to compare serum antibodies against genitourinary infectious agents between PCa patients and controls with benign prostate hyperplasia (BPH). We hypothesized that elevated serum antibody levels or higher seroprevalence in PCa patients would suggest an association of genitourinary infection in patient history and elevated PCa risk.
Permanent Link: http://hdl.handle.net/11104/0194886