Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy

0356090 - ÚMG 2011 RIV GB eng J - Journal Article
Záruba, K. - Králová, Jarmila - Řezanka, P. - Poučková, P. - Veverková, L. - Král, V.
Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy.
Organic & Biomolecular Chemistry. Roč. 8, č. 14 (2010), s. 3202-3206. ISSN 1477-0520. E-ISSN 1477-0539
R&D Projects: GA MŠMT(CZ) LC06077; GA ČR GA203/09/1311; GA AV ČR KAN200200651
Institutional research plan: CEZ:AV0Z50520514
Keywords : photothermal therapy * photosensitizers * agents
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.451, year: 2010

Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy (PDT) was assayed using the basaloid squamous cell carcinoma PE/CA-PJ34 cell line. In vitro PDT experiments revealed that the gold nanoparticle-bound conjugates were less effective than unbound conjugates in killing cells. However, the same conjugates were more effective in reducing tumor size in vivo, with complete tumor regression observed.
Permanent Link: http://hdl.handle.net/11104/0194706