Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis

0356081 - ÚMG 2011 RIV DE eng J - Journal Article
Kejík, Z. - Bříza, T. - Králová, Jarmila - Martásek, P. - Král, V.
Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis.
Analytical and Bioanalytical Chemistry. Roč. 398, č. 5 (2010), s. 1865-1870. ISSN 1618-2642. E-ISSN 1618-2650
R&D Projects: GA MŠMT(CZ) LC06077; GA ČR GA203/09/1311; GA AV ČR KAN200200651
Grant - others:GA MŠk(CZ) LC512
Program: LC
Institutional research plan: CEZ:AV0Z50520514
Keywords : extracellular-matrix components * hepatocellular carcinoma * breast cancer
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.841, year: 2010

It is well known that saccharides and their glycoconjugates can have an important influence on various serious pathologic stages such as cancer. They can regulate tumor proliferation, invasion, hematogenous metastasis, and angiogenesis. These facts clearly show the importance of cancer saccharide recognition. In medicine, sensor analysis is one of the best methods for recognition and determination of biologically important analytes. The development and study of sensors for saccharide tumor markers can open a new way for their detection. Therefore, this review is focused on recognition of saccharide-based cancer markers by natural or synthetic selective ligands working as bio- and chemosensors. The design and application of these ligands for cancer diagnosis is a useful direction of research. Moreover, it also opens the possibility of using these agents for the targeted drug transport required for advanced anticancer therapy.
Permanent Link: http://hdl.handle.net/11104/0194698