Pentacyclic Triterpenes as Promising Agents in Cancer

0355519 - ÚOCHB 2011 RIV US eng M - Monography Chapter
Šarek, J. - Kvasnica, Miroslav - Vlk, M. - Biedermann, David
Semisynthetic Lupane Triterpenes with Cytotoxic Activity.
Pentacyclic Triterpenes as Promising Agents in Cancer. New York: Nova Publishers, 2010 - (Salvador, J.), s. 159-189. ISBN 978-1-60876-973-5
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50200510
Keywords : triterpenes * cytotoxicity * derivatives
Subject RIV: FR - Pharmacology ; Medidal Chemistry

In this chapter, we will describe important natural and semisynthetic lupane triterpenoids with significant cyototoxic effects on cancer cell lines of different histogenetic origin. The main emphasis will be placed on the synthetic derivatives of betulinic acid, the most important cytotoxic agent among lupane triterpenes and betulin, the most readily available natural lupane from natural sources.
Permanent Link: http://hdl.handle.net/11104/0194269