Number of the records: 1
Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats
- 1.0355370 - FGÚ 2011 RIV US eng J - Journal Article
Bubeníková-Valešová, V. - Svoboda, Jan - Horáček, J. - Sumiyoshi, T.
Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats.
Psychopharmacology. Roč. 212, č. 2 (2010), s. 267-276. ISSN 0033-3158. E-ISSN 1432-2072
R&D Projects: GA MŠMT(CZ) 1M0517
Institutional research plan: CEZ:AV0Z50110509
Keywords : Tandospirone * Schizophrenia * NMDA receptor
Subject RIV: FH - Neurology
Impact factor: 3.817, year: 2010
These findings suggest that behavioural changes induced by tandospirone are not fully blocked by 5-HT1A antagonists and that tandospirone (5 mg/kg) potentiates the effect of MK-801. Overall, these findings point to an interaction between NMDA and 5-HT(1A) receptors. Part of the effect of tandospirone on locomotor activity may be mediated by the actions of its active metabolites on other neurotransmitter systems
Permanent Link: http://hdl.handle.net/11104/0194155
Number of the records: 1