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Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction
- 1.0355368 - FGÚ 2011 RIV CZ eng J - Journal Article
Adámek, S. - Shakirzyanova, V. - Malomouzh, A. I. - Naumenko, N. V. - Vyskočil, František
Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction.
Physiological Research. Roč. 59, č. 5 (2010), s. 803-810. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA AV ČR(CZ) IAA500110905; GA ČR GA202/09/0806
Institutional research plan: CEZ:AV0Z50110509
Keywords : Endplate potentials * Guanylyl cyclase
Subject RIV: ED - Physiology
Impact factor: 1.646, year: 2010
The depression of nerve stimulation evoked number of quanta (EPC) by glutamate was removed by inhibition of the NO production in the muscle and the NO cascade is common post-receptor pathway started by both glutamate and adenosine presynaptic receptors. Spontaneously released quanta (MEPCs) are not regulated by NO cascade in the presence of glutamate and its specific effect on the evoked release points to modulation (phosphorylation) of the voltage-dependent Ca2+ channels at the release zone that are necessary for evoked quantal release during nerve stimulation
Permanent Link: http://hdl.handle.net/11104/0194153
Number of the records: 1