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NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells
- 1.0355236 - BFÚ 2011 RIV US eng J - Journal Article
Krejčí, Pavel - Murakami, S. - Procházková, J. - Trantírek, L. - Chlebová, K. - Ouyang, Z. - Aklian, A. - Smutný, J. - Bryja, Vítězslav - Kozubík, Alois - Wilcox, W.R.
NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells.
Journal of Biological Chemistry. Roč. 285, č. 27 (2010), s. 20644-20653. ISSN 0021-9258. E-ISSN 1083-351X
Grant - others:GA ČR(CZ) GA301/09/0587
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : NF449 * fibroblast growth factor receptor * antagonist
Subject RIV: BO - Biophysics
Impact factor: 5.328, year: 2010
This article indentifies, for the first time, a NF449 compound as a novel inhibitor of FGFR3 signal transduction in vitro and in vivo. Various molecular aspects of NF449 action are described and discussed in the article, such as its effects on FGFR3 kinase activity, activation of downstream signaling molecules as well as effects on several cellular phenotypes regulated by FGFR3 signaling.
Permanent Link: http://hdl.handle.net/11104/0194054
Number of the records: 1