The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

0355121 - ÚMG 2011 RIV GB eng J - Journal Article
Brabek, J. - Mierke, C.T. - Rosel, D. - Veselý, Pavel - Fabry, B.
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.
Cell communication and signaling : CCS. Roč. 8, č. 22 (2010), 22e-22e. E-ISSN 1478-811X
R&D Projects: GA MŠMT(CZ) LC06061
Institutional research plan: CEZ:AV0Z50520514
Keywords : endothelial barrier function * pericellular proteolysis * melanoma cells
Subject RIV: EB - Genetics ; Molecular Biology

During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion.
Permanent Link: http://hdl.handle.net/11104/0193962