NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

0355110 - ÚMG 2011 RIV GR eng J - Journal Article
Indrová, Marie - Šímová, Jana - Bieblová, Jana - Bubeník, Jan - Reiniš, Milan
NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours.
Oncology Reports. Roč. 25, č. 1 (2011), s. 281-288. ISSN 1021-335X. E-ISSN 1791-2431
R&D Projects: GA AV ČR IAA500520807
Grant - others:EU-FP6-NOE(XE) Project 018933
Institutional research plan: CEZ:AV0Z50520514
Keywords : MHC class I-deficient tumours * CD8+, CD4+, NK1.1+cell subpopulations * interferon gamma
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.835, year: 2011

In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells..
Permanent Link: http://hdl.handle.net/11104/0193953