Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP

0354978 - ÚEM 2011 RIV GB eng J - Journal Article
Medvedev, N. I. - Popov, V. I. - Dallerac, G. - Davies, H.A. - Laroche, S. - Kraev, I. V. - Rodríguez Arellano, Jose Julio - Doyere, V. - Stewart, M.G.
Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-D-aspartate receptor antagonist CPP.
Neuroscience. Roč. 171, č. 2 (2010), s. 390-397. ISSN 0306-4522. E-ISSN 1873-7544
Institutional research plan: CEZ:AV0Z50390703
Keywords : D synaptic ultrastructure * hippocampus * long term potentiation and depression
Subject RIV: FH - Neurology
Impact factor: 3.215, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0354978_01.pdf

Alterations in curvature of the post synaptic density (PSD) and apposition zone (AZ), are believed to play an important role in determining synaptic efficacy. In the present study we have examined curvature of PSDs and AZs 24 h following homosynaptic long-term potentiation (LTP), and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats.Very large and significant changes in 3-D measurements of AZ and PSD curvature occurred 24 h following both LTP and LTD, with a flattening of the normal concavity of mushroom spine heads and a change to convexity for thin spines.
Permanent Link: http://hdl.handle.net/11104/0193854