Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic

0354964 - ÚEM 2011 RIV US eng J - Journal Article
Pratt, M. M. - King, L. C. - Adams, L. D. - John, K. - Sirajuddin, P. - Olivero, O. A. - Manchester, D. K. - Šrám, Radim - DeMarini, D. M. - Poirier, M. C.
Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic.
Environmental and Molecular Mutagenesis. Roč. 52, č. 1 (2011), s. 58-68. ISSN 0893-6692. E-ISSN 1098-2280
R&D Projects: GA MŽP(CZ) SP/1B3/8/08
Institutional research plan: CEZ:AV0Z50390512
Keywords : automated cellular imaging system * immunohistochemistry * BPDE-DNA antiserum
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.709, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0354964_01.pdf

Three classes of DNA damage were assessed in human placentas collected (2000-2004) from 51 women from the Teplice region, Czech Rep. More generalized DNA damage was measured both by 32P-postlabelling and by abasic (AB) site analysis. For both methods, there was no correlation among types of DNA damage and no difference in the extent of DNA damage between smokers and nonsmokers. The data show that DNA from placentas obtained in Teplice contained multiple types of DNA damage, which likely arose from various environmental exposures.
Permanent Link: http://hdl.handle.net/11104/0193848