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Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart
- 1.0354866 - FGÚ 2011 RIV US eng J - Journal Article
Hlaváčková, M. - Kožichová, K. - Neckář, Jan - Kolář, František - Musters, R.J.P. - Novák, O. - Nováková, O.
Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart.
Molecular and Cellular Biochemistry. Roč. 345, 1-2 (2010), s. 271-282. ISSN 0300-8177. E-ISSN 1573-4919
R&D Projects: GA ČR(CZ) GA305/07/0875; GA MŠMT(CZ) 1M0510
Grant - others:Univerzita Karlova(CZ) 97908
Institutional research plan: CEZ:AV0Z50110509
Keywords : protein kinase C * chronic intermittent hypoxia * heart
Subject RIV: ED - Physiology
Impact factor: 2.168, year: 2010
The aim of the study was to examine the effects of chronic intermittent hypoxia (CIH) and acute administration of PKC-delta inhibitor rottlerin on the expression and subcellular distribution of PKC-delta and PKC-epsilon in the left ventricular myocardium in rats. It has been shown that CIH up-regulated PKC-delta which was localized to mitochondrial and sarcolemmal membranes. The inhibitory effects of rottlerin on PKC-delta subcellular redistribution and cardioprotection (as shown previously) support the view that this isoform plays a role in the mechanism of CIH-induced ischemic tolerance
Permanent Link: http://hdl.handle.net/11104/0193773
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