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Molecular mass spectrometry imaging in biomedical and life science research
- 1.0354266 - MBÚ 2011 RIV DE eng J - Journal Article
Pól, Jaroslav - Strohalm, Martin - Havlíček, Vladimír - Volný, Michael
Molecular mass spectrometry imaging in biomedical and life science research.
Histochemistry and Cell Biology. Roč. 134, č. 5 (2010), s. 423-443. ISSN 0948-6143. E-ISSN 1432-119X
R&D Projects: GA MŠMT LC545; GA ČR GPP206/10/P018
Institutional research plan: CEZ:AV0Z50200510
Keywords : Mass spectrometry * Chemical imaging * Molecular imaging
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.727, year: 2010
This review describes the current state of mass spectrometry imaging (MSI) in life sciences. A brief overview of mass spectrometry principles is presented followed by a thorough introduction to the MSI workflows, principles and areas of application. Three major desorptionionization techniques used in MSI, namely, secondary ion mass spectrometry (SIMS), matrix-assisted laser desorption ionization (MALDI), and desorption electrospray ionization (DESI) are described, and biomedical and life science imaging applications of each ionization technique are reviewed. A separate section is devoted to data handling and current challenges and future perspectives are briefly discussed at the end
Permanent Link: http://hdl.handle.net/11104/0193307
Number of the records: 1