Inference of selection and random effects in the house mouse hybrid zone

0354073 - ÚBO 2012 RIV US eng J - Journal Article
Dufková, Petra - Macholán, Miloš - Piálek, Jaroslav
Inference of selection and random effects in the house mouse hybrid zone.
Evolution. Roč. 65, č. 4 (2011), s. 993-1010. ISSN 0014-3820. E-ISSN 1558-5646
R&D Projects: GA ČR GA206/08/0640; GA AV ČR IAA600930506; GA MŠMT LC06073
Institutional research plan: CEZ:AV0Z60930519; CEZ:AV0Z50450515
Keywords : cline analysis * Mus musculus * reproductive isolation * speciation * X chromosome
Subject RIV: EG - Zoology
Impact factor: 5.146, year: 2011

We explored the transition of 13 X-linked markers across two separate portions of the house mouse hybrid zone, asking whether such a comparison can distinguish the effects of selection from random factors. A heuristic search in the likelihood landscape revealed more complex likelihood profiles for data sampled in two-dimensional space relative to a linear transect. Randomized resampling of localities showed that deletion of sites away from the zone center can decrease cline width estimates whereas deletion of sites close to the center can significantly increase the width estimates. The results suggest that the geographic sampling design is very important in hybrid zone studies. The comparison of the two transects indicates cline widths are narrower for loci in the central part of the X chromosome, suggesting selection is stronger in this region and genetic incompatibilities may have at least partly common architecture in the house mouse hybrid zone.
Permanent Link: http://hdl.handle.net/11104/0193153