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Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension

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    0353982 - FGÚ 2011 RIV CZ eng J - Journal Article
    Hojná, Silvie - Kuneš, Jaroslav - Zicha, Josef
    Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension.
    Physiological Research. Roč. 59, č. 6 (2010), s. 997-1009. ISSN 0862-8408. E-ISSN 1802-9973
    R&D Projects: GA MŠMT(CZ) 1M0510; GA ČR(CZ) GA305/08/0139
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : brainstem * diencephalon * kidney
    Subject RIV: ED - Physiology
    Impact factor: 1.646, year: 2010

    Our study evaluated NO synthase (NOS) activity and protein expression of its three isoforms - neuronal (nNOS), endothelial NOS (eNOS) and inducible (iNOS) - in two brain regions involved in blood pressure control (diencephalon and brainstem) as well as in the kidney of rats with either genetic (SHR) or salt-induced hypertension (Dahl rats). We disclosed similar changes of NO system in the brainstem (but not in the diencephalon) of rats with genetic and salt-induced hypertension. Decreased nNOS expression was associated with increased blood pressure due to enhanced sympathetic tone
    Permanent Link: http://hdl.handle.net/11104/0193081

     
     
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