Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables

0353971 - ÚEM 2011 RIV GB eng J - Journal Article
Holland, N. - Fucic, A. - Merlo, D.F. - Šrám, Radim - Kirsch-Volders, M.
Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables.
Mutagenesis. Roč. 26, č. 1 (2011), s. 51-56. ISSN 0267-8357. E-ISSN 1464-3804
R&D Projects: GA MŽP(CZ) SP/1B3/8/08
Grant - others:European Union(XE) FOOD-CT-2005-513943; European Union(XE) FOOD-CT-2005-016320
Institutional research plan: CEZ:AV0Z50390512
Keywords : Micronucleus assay * newborns * children
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.183, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0353971_01.pdf

This is an overview of the micronucleus (MN) assay in lymphocytes and exfoliated epithelial cells of children from birth to adolescence. The article briefly describes the effect of age and sex in different cell types, the use of the MN assay for monitoring of environmental exposures and characterisation of MN levels in children with various diseases and their treatment. The relationship of MN as biomarkers of genotoxicity with other markers, such as genetic polymorphisms and gene expression is also discussed. In the last section, an attempt was made to summarize the current state of knowledge and significant achievements in genotoxicity research in children.
Permanent Link: http://hdl.handle.net/11104/0193071