Number of the records: 1
Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations
- 1.0353799 - BFÚ 2011 RIV US eng J - Journal Article
Reshetnikov, R. - Golovin, A. - Spiridonova, V. - Kopylov, A. - Šponer, Jiří
Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations.
Journal of Chemical Theory and Computation. Roč. 6, č. 10 (2010), s. 3003-3014. ISSN 1549-9618. E-ISSN 1549-9626
R&D Projects: GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476; GA MŠMT(CZ) LC06030
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : molecular dynamics * quadruplex DNA * thrombin
Subject RIV: BO - Biophysics
Impact factor: 5.138, year: 2010
The thrombin-binding aptamer (15-TBA) is a 15-mer DNA oligonucleotide with sequence d(GGTTGGTGTGGTTGG). 15-TBA folds into a quadruplex DNA (G-DNA) structure with two planar G-quartets connected by three single-stranded loops. In the present study, the explicit solvent molecular dynamics (MD) simulation method was utilized to analyze the 15-TBA-thrombin threedimensional structure.
Permanent Link: http://hdl.handle.net/11104/0192943
Number of the records: 1