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Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro
- 1.0353781 - BFÚ 2011 RIV US eng J - Journal Article
Kostrhunová, Hana - Vrána, Oldřich - Suchánková, T. - Gibson, D. - Kašpárková, Jana - Brabec, Viktor
Different features of the DNA binding mode of antitumor cis-amminedichlorido(cyclohexylamine)platinum(II) (JM118) and cisplatin in vitro.
Chemical Research in Toxicology. Roč. 23, č. 11 (2010), s. 1833-1842. ISSN 0893-228X. E-ISSN 1520-5010
R&D Projects: GA MŠMT(CZ) ME08017; GA MŠMT(CZ) ME10066; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GAP301/10/0598
Grant - others:GA MŠk(CZ) LC06030; GA MŠk(CZ) OC09018; GA AV ČR(CZ) KAN200200651
Program: LC; KA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : JM118 * DNA bending * DNA-protein cross-linking
Subject RIV: BO - Biophysics
Impact factor: 4.148, year: 2010
JM118 is the major metabolite of satraplatin. The results of DNA-protein cross-linking assay and DNA repair synthesis by cell-free extract showed a higher DNA-protein cross-linking efficiency of JM118 and less efficient removal from DNA of the adducts of JM118 in comparison with cisplatin.
Permanent Link: http://hdl.handle.net/11104/0192929
Number of the records: 1