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Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
- 1.0353777 - BFÚ 2011 RIV US eng J - Journal Article
Kostrhunová, Hana - Kašpárková, Jana - Gibson, D. - Brabec, Viktor
Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione.
Molecular Pharmaceutics. Roč. 7, č. 6 (2010), s. 2093-2102. ISSN 1543-8384. E-ISSN 1543-8392
R&D Projects: GA MŠMT(CZ) ME08017; GA MŠMT(CZ) ME10066; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GAP301/10/0598
Grant - others:GA MŠk(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Program: LC; KA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : JM118 * cellular accumulation * glutathione
Subject RIV: BO - Biophysics
Impact factor: 5.400, year: 2010
The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA.
Permanent Link: http://hdl.handle.net/11104/0006241
Number of the records: 1