Bulky DNA adducts in white blood cells: a pooled analysis of 3600 subjects

0353745 - ÚEM 2011 RIV US eng J - Journal Article
Ricceri, F. - Godschalk, R. W. - Peluso, M. - Philips, D. H. - Agudo, A. - Georgiadis, P. - Loft, S. - Tjonneland, A. - Raaschau-Nielsen, O. - Palli, D. - Perera, F. - Vermeulen, R. - Taioli, E. - Šrám, Radim - Munnia, A. - Rosa, F. - Allione, A. - Matullo, G. - Vineis, P.
Bulky DNA adducts in white blood cells: a pooled analysis of 3600 subjects.
Cancer Epidemiology Biomarkers & Prevention. Roč. 19, č. 12 (2010), s. 3174-3181. ISSN 1055-9965. E-ISSN 1538-7755
Grant - others:European Union ECNIS(XE) FOOD-CT-2005-513943
Institutional research plan: CEZ:AV0Z50390512
Keywords : DNA adducts * biomarkers of exposure * air pollution
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 4.190, year: 2010

Eleven studies (3,600 subjects) were compared, in which bulky DNA adducts were measured in human white blood cells with similar 32P-postlabelling techniques and for which a similar set of variables was available (data on age, gender, ethnicity, smoking, season of blood collection and a limited set of gene variants). Only weak association between bulky DNA adducts and exposure variables was found. Seasonality (with higher adducts levels in winter) and air pollution may partly explain some of the inter-area differences (North vs. South Europe), but most inter-area and inter-individual variations in adduct levels still remain unexplained.
Permanent Link: http://hdl.handle.net/11104/0192901