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Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs
- 1.0353069 - ÚŽFG 2011 RIV US eng J - Journal Article
Usvald, Dušan - Vodička, Petr - Hlučilová, Jana - Procházka, Radek - Motlík, Jan - Kuchorova, K. - Johe, K. - Marsala, S. - Scadeng, M. - Kakinohana, O. - Navarro, R. - Santa, M. - Hefferan, M. P. - Yaksh, T.L. - Marsala, M.
Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs.
Cell Transplantation. Roč. 19, č. 9 (2010), s. 1103-1122. ISSN 0963-6897. E-ISSN 1555-3892
Institutional research plan: CEZ:AV0Z50450515
Keywords : minipigs * human spinal stem cells * analysis
Subject RIV: FH - Neurology
Impact factor: 6.204, year: 2010
In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and corresponding improvement in ambulatory function. In the present study, we characterized the optimal dosing regimen and safety profile of human spinal stem cells (HSSC) when grafted into the lumbar spinal cord segments of naive immunosuppressed minipigs
Permanent Link: http://hdl.handle.net/11104/0192413
Number of the records: 1