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Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs

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    0353069 - ÚŽFG 2011 RIV US eng J - Journal Article
    Usvald, Dušan - Vodička, Petr - Hlučilová, Jana - Procházka, Radek - Motlík, Jan - Kuchorova, K. - Johe, K. - Marsala, S. - Scadeng, M. - Kakinohana, O. - Navarro, R. - Santa, M. - Hefferan, M. P. - Yaksh, T.L. - Marsala, M.
    Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs.
    Cell Transplantation. Roč. 19, č. 9 (2010), s. 1103-1122. ISSN 0963-6897. E-ISSN 1555-3892
    Institutional research plan: CEZ:AV0Z50450515
    Keywords : minipigs * human spinal stem cells * analysis
    Subject RIV: FH - Neurology
    Impact factor: 6.204, year: 2010

    In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and corresponding improvement in ambulatory function. In the present study, we characterized the optimal dosing regimen and safety profile of human spinal stem cells (HSSC) when grafted into the lumbar spinal cord segments of naive immunosuppressed minipigs
    Permanent Link: http://hdl.handle.net/11104/0192413

     
     
Number of the records: 1  

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