Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

0352928 - ÚOCHB 2011 RIV GB eng J - Journal Article
Synytsya, A. - Kim, W. J. - Kim, S. M. - Pohl, Radek - Synytsya, Al. - Kvasnička, F. - Čopíková, J. - Park, Y. I.
Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida.
Carbohydrate Polymers. Roč. 81, č. 1 (2010), s. 41-48. ISSN 0144-8617. E-ISSN 1879-1344
Institutional research plan: CEZ:AV0Z40550506
Keywords : fucoidan from sporophyll Undaria pinnatifida * structure * antitumour activity
Subject RIV: CC - Organic Chemistry
Impact factor: 3.463, year: 2010

Fucoidan from the sporophyll (Miyeokgui) Korean brown seaweeds Undaria pinnatifida was isolated from raw material by dilute acid extraction, ballast alginates were removed by CaCl2 precipitation, and crude extract was purified by chromatography on DEAE–cellulose. Structure and composition of the fucoidan was characterised by various methods (organic elemental analysis, HPLC analysis of neutral sugars, FTIR, FT-Raman, 1H and 13C NMR); molecular size and charge density were estimated by GPC and CITP. The Miyeokgui fucoidan showed antitumour activity against PC-3 (prostate cancer), HeLa (cervical cancer), A549 (alveolar carcinoma), and HepG2 (hepatocellular carcinoma) cells.
Permanent Link: http://hdl.handle.net/11104/0192311