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Synthesis and Biochemical Characterization of a Series of 17alpha-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor alpha
- 1.0352926 - ÚOCHB 2011 RIV US eng J - Journal Article
Eignerová, B. - Sedlák, David - Dračínský, Martin - Bartůněk, Petr - Kotora, Martin
Synthesis and Biochemical Characterization of a Series of 17alpha-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor alpha.
Journal of Medicinal Chemistry. Roč. 53, č. 19 (2010), s. 6947-6953. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LC06077; GA AV ČR IAA400550609
Grant - others:GA MŠk(CZ) LC06070
Program: LC
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : estrogen receptor * estradiols * selective ligands
Subject RIV: CC - Organic Chemistry
Impact factor: 5.207, year: 2010
Synthesis of a new class of potent and selective ligands for estrogen receptor alpha represented by a series of 17alpha-substituted estradiolsbearing lipophilic perfluoroalkyl chains.These estradiols were synthetized by Ru-catalyzed cross metathesis reactions.
Permanent Link: http://hdl.handle.net/11104/0192310
Number of the records: 1