Number of the records: 1
Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids
- 1.0352909 - MBÚ 2011 RIV DE eng J - Journal Article
Biedermann, David - Eignerová, B. - Hajdúch, M. - Sarek, J.
Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids.
Synthesis. Roč. 42, č. 22 (2010), s. 3839-3848. ISSN 0039-7881. E-ISSN 1437-210X
Institutional research plan: CEZ:AV0Z50200510
Keywords : amines * terpenoids * esters
Subject RIV: CC - Organic Chemistry
Impact factor: 2.260, year: 2010
The anticancer properties of the derivatives of natural pentacyclic triterpenoids have received much attention recently. Here we present the preparation and the evaluation of the anticancer activity of a novel group of derivatives: quaternary ammonium esters. The esters were synthesized by quaternization of the respektive 2-bromoethyl esters of betulinic, dihydrobetulinic, platanic, oleanolic, ursolic, and 3b-acetoxy-21-oxolup-18-en-28-oic acids with common low-molecular-weight tertiary amines, namely trimethylamine, triethylamine, pyridine, and triethanolamine
Permanent Link: http://hdl.handle.net/11104/0192297
Number of the records: 1