Number of the records: 1
Absence of Microbiota (Germ-Free Conditions) Accelerates the Atherosclerosis in ApoE-Deficient Mice Fed Standard Low Cholesterol Diet
- 1.0352895 - MBÚ 2011 RIV JP eng J - Journal Article
Štěpánková, Renata - Tonar, Z. - Bártová, J. - Nedorost, L. - Rossmann, Pavel - Poledne, R. - Schwarzer, Martin - Tlaskalová-Hogenová, Helena
Absence of Microbiota (Germ-Free Conditions) Accelerates the Atherosclerosis in ApoE-Deficient Mice Fed Standard Low Cholesterol Diet.
Journal of Atherosclerosis and Thrombosis. Roč. 17, č. 8 (2010), s. 796-804. ISSN 1340-3478. E-ISSN 1880-3873
R&D Projects: GA MZd NS9775; GA ČR GA303/08/0367; GA ČR GA305/08/0535; GA AV ČR 1QS500200572; GA MŠMT 2B06155
Institutional research plan: CEZ:AV0Z50200510
Keywords : Germ-free mice * Commensal bacteria * Atherogenesis
Subject RIV: EC - Immunology
Impact factor: 2.293, year: 2010
The aim of our work was to determine the influence of intestinal bacteria on the development of atherosclerotic lesions using apolipoprotein E (ApoE)-deficient knockout mice. The experiments were performed on ApoE deficient mouse strain C57BL/6, bred under germ-free (GF) conditions for two generations or under conventional conditions with defined microflora (CV).
Permanent Link: http://hdl.handle.net/11104/0192287
Number of the records: 1