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Synthesis of Phenol and Pyridone C-Ribo-and 2'-Deoxyribonucleosides by Palladium-Catalyzed Hydroxylations of Haloaryl C-Nucleosides
- 1.0352060 - ÚOCHB 2011 RIV DE eng J - Journal Article
Štefko, Martin - Hocek, Michal
Synthesis of Phenol and Pyridone C-Ribo-and 2'-Deoxyribonucleosides by Palladium-Catalyzed Hydroxylations of Haloaryl C-Nucleosides.
Synthesis. -, č. 24 (2010), s. 4199-4206. ISSN 0039-7881. E-ISSN 1437-210X
R&D Projects: GA MŠMT LC512; GA AV ČR IAA400550902
Institutional research plan: CEZ:AV0Z40550506
Keywords : nucleosides * cross-coupling reactions * hydroxylation
Subject RIV: CC - Organic Chemistry
Impact factor: 2.260, year: 2010
Phenol and pyridone C-nucleosides in both ribo- and deoxyribo series were prepared by palladium-catalyzed hydroxylations reactions from the corresponding TBS-protected bromophenyl and bromo- or chloropyridyl C-nucleosides using Buchwald-type ligand under mild conditions. Free nucleosides (7 examples) were obtained in good overall yields by cleavage of TBS-protecting groups with Et3N·3HF.
Permanent Link: http://hdl.handle.net/11104/0191657
Number of the records: 1