Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

0351994 - BTÚ 2011 RIV US eng J - Journal Article
Bohuslavová, Romana - Kolář, František - Kuthanová, Lada - Neckář, Jan - Tichopád, Aleš - Pavlínková, Gabriela
Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia.
Journal of Applied Physiology. Roč. 109, č. 4 (2010), s. 1195-1202. ISSN 8750-7587. E-ISSN 1522-1601
R&D Projects: GA ČR GA301/09/0117
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50110509
Keywords : Hypoxia inducible factor 1 alpha * hypoxia * gene expression profiling
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.232, year: 2010

Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11 analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia
Permanent Link: http://hdl.handle.net/11104/0191609