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Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
- 1.0351889 - ÚT 2011 RIV SE eng J - Journal Article
Bébarová, M. - Matejovič, P. - Pásek, Michal - Ohlídalová, D. - Jansová, D. - Šimurdová, M. - Šimurda, J.
Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes.
Acta Physiologica. Roč. 200, č. 4 (2010), s. 301-314. ISSN 1748-1708. E-ISSN 1748-1716
Institutional research plan: CEZ:AV0Z20760514
Keywords : action potential * ethanol * rat ventricular myocyte
Subject RIV: BO - Biophysics
Impact factor: 3.138, year: 2010
http://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=15&SID=Y1pmpi@7k2HPEc8ehEE&page=1&doc=1&colname=WOS
Ethanol belongs to the group of agents that significantly affect the function of cardiac myocytes. The results of performed experiments showed that ethanol reversibly decelerates the upstroke velocity of action potential and decreases its amplitude and duration. Further exploration of the effect of ethanol on membrane ionic currents showed, that ethanol efficiently suppresses INa, ICa and Ito with 50% inhibition at 446 mM, 553 mM a 1954 mM, respectively.
Permanent Link: http://hdl.handle.net/11104/0191533
Number of the records: 1