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Modeling of nucleolar self-assembly
- 1.0351861 - ÚEM 2011 RIV CZ eng C - Conference Paper (international conference)
Blažíková, Michaela - Heřman, P. - Malínský, Jan
Modeling of nucleolar self-assembly.
MS'10 Prague. Prague: Czech Technical University, 2010, s. 34-37. ISBN 978-80-01-04574-9.
[Proceedings of the International Conference on Modelling and Simulation 2010. Praha (CZ), 22.06.2010-25.06.2010]
R&D Projects: GA ČR GA204/07/0133
Grant - others:GA AV ČR(CZ) KAN200520801; GA MŠk(CZ) 0021620835
Program: IA
Institutional research plan: CEZ:AV0Z50390512
Keywords : Monte Carlo simulations
Subject RIV: EB - Genetics ; Molecular Biology
Mammalian cell nucleoli disassemble at the beginning of mitosis and reassemble again during telophase and the early G1. Dynamics of this process was studied using a model based on entropy driven self-assembly of pre-ribosomal particles generated in a single biosynthetic source. Monte Carlo simulations revealed that such model can explain formation of a large aggregate, a nucleolus, in the vicinity of the source. We examined influence of nucleoplasm properties on dynamics of the aggregate formation.
Permanent Link: http://hdl.handle.net/11104/0191512
Number of the records: 1