Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation

0351847 - ÚEM 2011 RIV US eng J - Journal Article
Rampichová, Michala - Filová, Eva - Varga, F. - Lytvynets, Andriy - Prosecká, Eva - Koláčná, Lucie - Motlík, Jan - Nečas, A. - Vajner, L. - Uhlík, J. - Amler, Evžen
Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation.
Asaio Journal. Roč. 56, č. 6 (2010), s. 563-568. ISSN 1058-2916. E-ISSN 1538-943X
R&D Projects: GA ČR GAP304/10/1307
Grant - others:GA MŠk(CZ) 2B06130; GA ČR.(CZ) GA202/09/1151; EU(XE) BIOSCENT ID214539; GA UK(CZ) 119209
Program: 2B; GA
Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50390703; CEZ:AV0Z50450515
Keywords : chondrocyte * composite scaffold * osteochondral defect regeneration
Subject RIV: BO - Biophysics
Impact factor: 1.221, year: 2010

Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP).
Permanent Link: http://hdl.handle.net/11104/0191503