Clinical adenoviral gene therapy for prostate cancer

0351752 - ÚMCH 2011 US eng J - Journal Article
Schenk, E. - Essand, M. - Bangma, Ch. H. - Barber, Ch. - Behr, J.-P. - Briggs, S. - Carlisle, R. - Cheng, W.-S. - Danielsson, A. - Dautzenberg, I. J. C. - Dzojic, H. - Erbacher, P. - Fisher, K. - Frazier, A. - Georgopoulos, L. J. - Hoeben, R. - Kochanek, S. - Koppers-Lalic, D. - Kraaij, R. - Kreppel, F. - Lindholm, L. - Magnusson, M. - Maitland, N. - Neuberg, P. - Nilsson, B. - Ogris, M. - Remy, J.-S. - Scaife, M. - Schooten, E. - Seymour, L. - Totterman, T. - Uil, T. G. - Ulbrich, Karel - Veldhoven-Zweistra, J. L. M. - de Vrij, J. - van Weerden, W. - Wagner, E. - Willemsen, R.
Clinical adenoviral gene therapy for prostate cancer.
Human Gene Therapy. Roč. 21, č. 7 (2010), s. 807-813. ISSN 1043-0342. E-ISSN 1557-7422
EU Projects: European Commission(XE) 512087 - GIANT
Keywords : adenovirus * gene delivery * prostate cancer
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.829, year: 2010

Prostate cancer is at present the most common malignancy in men in the Western world. When localized, this disease can be treated by curative therapy such as surgery and radiotherapy. Unfortunately, for advanced stage of the disease only palliative treatment is available. Therefore, there is a clinical need for new treatment modalities that can, on the one hand, enhance the cure rate of primary therapy for localized prostate cancer and, on the other hand, improve the treatment of metastasized disease. Gene therapy is now being explored in the clinic as a treatment option for the various stages of prostate cancer. Current clinical experiences are based predominantly on trials with adenoviral vectors. As the first of a trilogy of reviews on the state of the art and future prospects of gene therapy in prostate cancer, this review focuses on the clinical experiences and progress of adenovirus-mediated gene therapy for this disease.
Permanent Link: http://hdl.handle.net/11104/0006173