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Determination of acid-base dissociation constants of very weak zwitterionic heterocyclic bases by capillary zone electrophoresis
- 1.0351530 - ÚOCHB 2011 RIV NL eng J - Journal Article
Ehala, Sille - Grishina, Anastasia - Sheshenev, Andrey - Lyapkalo, Ilya - Kašička, Václav
Determination of acid-base dissociation constants of very weak zwitterionic heterocyclic bases by capillary zone electrophoresis.
Journal of Chromatography A. Roč. 1217, - (2010), s. 8048-8053. ISSN 0021-9673. E-ISSN 1873-3778
R&D Projects: GA ČR(CZ) GA203/08/1428; GA ČR(CZ) GA203/09/0675
Institutional research plan: CEZ:AV0Z40550506
Keywords : acidity constant * capillary zone electrophoresis * zwitterionic heterocyclic bases
Subject RIV: CC - Organic Chemistry
Impact factor: 4.194, year: 2010
Thermodynamic acid-base dissociation (ionization) constants (pKa) of seven very weak zwitterionic heterocyclic bases, originally designed as chiral Lewis base catalysts for enantioselective reactions, were determined by capillary zone electrophoresis (CZE). The pKa values of these compounds were found to be particularly low, in the range 0.04-0.32. Moreover, from the pH dependence of effective mobility of the bases, some other relevant characteristics, such as actual and absolute ionic mobilities and hydrodynamic radii of the acidic cationic forms of the bases were determined.
Permanent Link: http://hdl.handle.net/11104/0191264
Number of the records: 1