RTX proteins: a highly diverse family secreted by a common mechanism

0351522 - MBÚ 2011 RIV US eng J - Journal Article
Linhartová, Irena - Bumba, Ladislav - Mašín, Jiří - Basler, Marek - Osička, Radim - Kamanová, Jana - Procházková, Kateřina - Adkins, Irena - Hejnová-Holubová, Jana - Sadílková, Lenka - Morová, Jana - Šebo, Peter
RTX proteins: a highly diverse family secreted by a common mechanism.
FEMS Microbiology Reviews. Roč. 34, č. 6 (2010), s. 1076-1112. ISSN 0168-6445. E-ISSN 1574-6976
R&D Projects: GA AV ČR IAA500200914; GA MŠMT 2B06161; GA MŠMT 1M0506; GA AV ČR KAN200520702; GA ČR GA310/08/0447; GA ČR GP310/09/P582; GA ČR GP310/07/P115; GA ČR GP204/07/P105
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z50520701
Keywords : bacterial toxin * type I secretion system * RTX locus
Subject RIV: EE - Microbiology, Virology
Impact factor: 11.796, year: 2010

Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export across the bacterial envelope via the type I secretion system and the characteristic, typically nonapeptide, glycine- and aspartate-rich repeats binding Ca ions. In this review, we summarize the current state of knowledge on the organization of rtx loci and on the biological and biochemical activities of therein encoded proteins. Applying several types of bioinformatic screens on the steadily growing set of sequenced bacterial genomes, over 1000 RTX family members were detected, with the biological functions of most of them remaining to be characterized
Permanent Link: http://hdl.handle.net/11104/0191258