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Do we need new antibiotics? The search for new targets and new compounds
- 1.0351521 - MBÚ 2011 RIV DE eng J - Journal Article
Spížek, Jaroslav - Novotná, Jitka - Řezanka, Tomáš - Demain, L. A.
Do we need new antibiotics? The search for new targets and new compounds.
Journal of Industrial Microbiology & Biotechnology. Roč. 37, č. 12 (2010), s. 1241-1248. ISSN 1367-5435. E-ISSN 1476-5535
Institutional research plan: CEZ:AV0Z50200510
Keywords : Antibiotics * Infectious diseases * Antibiotic resistance
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.416, year: 2010
Resistance to antibiotics and other antimicrobial compounds continues to increase. There are several possibilities for protection against pathogenic microorganisms, for instance, preparation of new vaccines against resistant bacterial strains, use of specific bacteriophages, and searching for new antibiotics. The antibiotic search includes: (1) looking for new antibiotics from nontraditional or less traditional sources, (2) sequencing microbial genomes with the aim of finding genes specifying biosynthesis of antibiotics, (3) analyzing DNA from the environment (metagenomics), (4) reexamining forgotten natural compounds and products of their transformations, and (5) investigating new antibiotic targets in pathogenic bacteria
Permanent Link: http://hdl.handle.net/11104/0191257
Number of the records: 1