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Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling
- 1.0351450 - ÚOCHB 2011 RIV GB eng J - Journal Article
Nencka, Radim - Sinnaeve, D. - Karalic, I. - Martins, J. C. - Calenbergh, Van S.
Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling.
Organic & Biomolecular Chemistry. Roč. 8, č. 22 (2010), s. 5234-5246. ISSN 1477-0520. E-ISSN 1477-0539
Institutional research plan: CEZ:AV0Z40550506
Keywords : ligand-free * Suzuki-Miyaura cross-coupling * phosphonate
Subject RIV: CC - Organic Chemistry
Impact factor: 3.451, year: 2010
An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki–Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates.
Permanent Link: http://hdl.handle.net/11104/0191204
Number of the records: 1