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Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity
- 1.0351324 - ÚOCHB 2011 RIV AT eng J - Journal Article
Niederhafner, Petr - Bednárová, Lucie - Buděšínský, Miloš - Šafařík, Martin - Ehala, Sille - Ježek, Jan - Borovičková, Lenka - Fučík, Vladimír - Čeřovský, Václav - Slaninová, Jiřina
Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity.
Amino Acids. Roč. 39, č. 5 (2010), s. 1553-1561. ISSN 0939-4451. E-ISSN 1438-2199
R&D Projects: GA ČR GA203/03/1362; GA ČR GA203/09/1919
Institutional research plan: CEZ:AV0Z40550506
Keywords : melectin * antibacterial peptides * dendrimers * hemolytic activity
Subject RIV: CC - Organic Chemistry
Impact factor: 4.106, year: 2010
The influence of dimerization and tetramerization of peptide melectin (GFLSILKKVLPKVMAHMK-NH2) on its antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of its peptide chain, was studied. 23 new analogues were synthesized. Dimerization and tetramerization increased the undesirable hemolytic activity. Introduction of the isosteric amino acid Nle into positions 14 or 17 or both led to only slight increase of hemolytic activity under preservation of high antimicrobial activities. Substitution of Leu for Val in position 6 led to the decrease of hemolytic activity.
Permanent Link: http://hdl.handle.net/11104/0191102
Number of the records: 1