Malignant mesothelioma: biology, diagnosis and therapeutic approaches

0351303 - ÚMG 2011 RIV AE eng J - Journal Article
Tomasetti, M. - Amati, M. - Santarelli, L. - Alleva, R. - Neužil, Jiří
Malignant mesothelioma: biology, diagnosis and therapeutic approaches.
Current Molecular Pharmacology. Roč. 2, č. 2 (2009), s. 190-206. ISSN 1874-4672. E-ISSN 1874-4702
Institutional research plan: CEZ:AV0Z50520514
Keywords : malignant mesothelioma * biology * diagnosis and therapeutic approaches
Subject RIV: EB - Genetics ; Molecular Biology

Malignant mesothelioma (MM) is an aggressive neoplasm of serosal cavities, which is resistant to conventional therapy, with patient survival from presentation of less than 12 months. MM remains a universally fatal disease of increasing incidence worldwide. Although the main risk factor is asbestos exposure, other factors, Simian virus 40 infection and inheritance of susceptibility genes, likely play a role. Asbestos-related carcinogenic process is primarily based on the interaction between susceptibility (genetic and acquired) and exposure to carcinogenic environmental agents. The long promotion phase observed in MM pathogenesis and the absence of early symptoms both contribute to late diagnosis of the disease. This results in delayed therapeutic intervention of patients, making the outcome of the disease very grim. This review presents recent developments in the pathogenesis, diagnosis and new therapeutic approaches of MM.
Permanent Link: http://hdl.handle.net/11104/0191086