Handbook of Materials for Nanomedicine

0351235 - ÚMCH 2011 RIV SG eng M - Monography Chapter
Ulbrich, Karel - Šubr, Vladimír
Synthetic polymer-drug conjugates for human therapy.
Handbook of Materials for Nanomedicine. Singapore: Pan Stanford Publishing Pte Ltd, 2010 - (Torchilin, V.; Amiji, M.), s. 5-79. ISBN 978-981-4267-55-7
R&D Projects: GA AV ČR IAAX00500803
Institutional research plan: CEZ:AV0Z40500505
Keywords : drug delivery * polymer-drug conjugates * drug targeting
Subject RIV: CD - Macromolecular Chemistry
http://www.panstanford.com/books/nanosci/v130.html

Polymer-drug conjugates represent a novel generation of polymer therapeutics enabling site-specific drug action what predestines them predominantly for tumor therapy. In this review a design, synthesis and physico-chemical and biological properties of water-soluble synthetic polymer-drug conjugates including principles of tumor-specific passive and tumor cell-specific active targeting, controlled drug release and elimination of the polymer drug carrier from organism is discussed and potential of polymer-drug conjugates for tumor treatment is evaluated.
Permanent Link: http://hdl.handle.net/11104/0191032