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Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice
- 1.0351174 - BFÚ 2011 RIV US eng J - Journal Article
Rudolph, T.K. - Rudolph, V. - Edreira, M.M. - Cole, M.P. - Bonacci, G. - Schopfer, F.J. - Woodcock, S.R. - Franek, A. - Pekarová, Michaela - Khoo, N.K.H. - Hasty, A.H. - Baldus, S. - Freeman, B.A.
Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis Thrombosis and Vascular Biology. Roč. 30, č. 5 (2010), s. 938-945. ISSN 1079-5642. E-ISSN 1524-4636
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : nitro-fatty acids * atherosclerosis * foam cells
Subject RIV: BO - Biophysics
Impact factor: 7.215, year: 2010
Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide- and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.
Permanent Link: http://hdl.handle.net/11104/0190981
Number of the records: 1