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Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation
- 1.0350954 - ÚOCHB 2011 RIV GB eng J - Journal Article
Hiraoka, N. - Ino, Y. - Sekine, S. - Tsuda, H. - Shimada, K. - Kosuge, T. - Závada, Jan - Yoshida, M. - Yamada, K. - Koyama, T. - Kanai, Y.
Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation.
British Journal of Cancer. Roč. 103, č. 7 (2010), s. 1057-1065. ISSN 0007-0920. E-ISSN 1532-1827
Institutional research plan: CEZ:AV0Z40550506
Keywords : pancreatic cancer * hypoxia * prognostics
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.831, year: 2010
Hypoxia is a major factor of increased invasivity of cancer, resulting in a poor prognosis. In tumor sections, it is manifested by necrotic foci and expression of CAIX protein. We investigated 248 patients with pancreatic ductal carcinoma and correlated necrosis and CAIX with the lenght of survival. SAIX is a biomarker which can easily be evaluated by independent scientists.
Permanent Link: http://hdl.handle.net/11104/0190811
Number of the records: 1