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Nanostructured complexes of polyelectrolytes and charged polypeptides
- 1.0350917 - ÚMCH 2011 RIV DE eng J - Journal Article
Müller, M. - Ouyang, W. - Bohatá, Karolína - Kessler, B.
Nanostructured complexes of polyelectrolytes and charged polypeptides.
Advanced Engineering Materials. Roč. 12, Sp. Iss. 9 (2010), B519-B528. ISSN 1438-1656. E-ISSN 1527-2648.
[Sino-German Symposium on Advanced Biomedical Nanostructures /1./. Jena, 26.10.2009-30.10.2009]
Institutional research plan: CEZ:AV0Z40500505
Keywords : situ ATR-FTIR * alpha-helical polypeptides * multilayer films
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 1.746, year: 2010
Nanoparticles and films of complexes between polyelectrolytes (PELs) and oppositely charged polypeptides emphasizing the influence of PEL molecular stiffness on the generated nanostructures are reported. Homopolypeptides like cationic poly(L-lysine) (PLL) and anionic poly(L-glutamic acid) (PLG) were used, whose conformations can be changed from random coil to α-helix by salt type or pH value. Randomly coiled PLL caused spherical PEC particles and isotropically structured PEM films. For PEM films consisting of PDADMAC/PLG PLG terminating PEM-6 was proteininert, while PDADMAC terminating PEM-7 was proteinactive. PEM films consisting of PDL/PSS showed higher enantiospecific adsorption of α-helical myoglobin compared to PLL/PSS. These nanoparticles and films are envisioned as bioinert and bioactive material substrates, unidirectional cell growth, polymer/cell scaffolds, and nanocarriers.
Permanent Link: http://hdl.handle.net/11104/0006153
Number of the records: 1