Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

0350688 - ÚEM 2011 RIV US eng J - Journal Article
Albizu, L. - Cottet, M. - Králíková, Michaela - Stoev, S. - Steyer, R. - Brabet, I. - Roux, T. - Bazin, H. - Bourrier, E. - Lamarque, L. - Breton, C. - Rives, M. L. - Newman, A. H. - Javitch, J. A. - Trinquet, E. - Manning, M. - Pin, J. P. - Mouillac, B. - Durroux, T.
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
Nature Chemical Biology. Roč. 6, č. 8 (2010), s. 587-594. ISSN 1552-4450. E-ISSN 1552-4469
Institutional research plan: CEZ:AV0Z50390512
Keywords : G protein-coupled receptor * FRET
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 15.808, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0350688_01.pdf

The artical "Time-resolved FRET between GPCR ligands reveals oligomers in native tissues" shows for the first time that G-protein coupled receptors (GPCRs) form oligomeric complexes also in native tissues and not only in heterologous expression systems. Oligomerization of these receptors regulates their function and pharmacological properties and thus influences all the processes controled by GPCRs that are involved in the cell response to extracellular stimuli.
Permanent Link: http://hdl.handle.net/11104/0190624