Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes

0350431 - ÚEM 2011 RIV DE eng J - Journal Article
Palygin, O. - Lalo, U. - Verkhratsky, Alexei - Pankratov, Y.
Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes.
Cell Calcium. Roč. 48, č. 4 (2010), s. 225-231. ISSN 0143-4160. E-ISSN 1532-1991
R&D Projects: GA ČR GA305/08/1384
Institutional research plan: CEZ:AV0Z50390703
Keywords : Astroglia * Ca2+ signalling * NMDA receptors
Subject RIV: FH - Neurology
Impact factor: 3.553, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0350431_01.pdf

These results demonstrate that activation of astroglial ionotropic NMDA and P2X1/5 receptors increases intracellular free calcium in cortical astrocytes when stimulated by endogenous agonists and synaptic release of neurotransmitters. These data suggest contribution of NMDA and P2X1/5 receptors to astroglial calcium signalling, which may provide a specific mechanism for fast neuronal-glial signalling at the synaptic level.
Permanent Link: http://hdl.handle.net/11104/0190443