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CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis
- 1.0350375 - MBÚ 2011 RIV US eng J - Journal Article
Richter, Jan - Benson, Veronika - Grobárová, Valeria - Svoboda, Jan - Vencovský, J. - Svobodová, R. - Fišerová, Anna
CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis.
Clinical Immunology. Roč. 136, č. 1 (2010), s. 139-147. ISSN 1521-6616. E-ISSN 1521-7035
R&D Projects: GA ČR GA310/06/0477; GA ČR GD310/08/H077; GA MZd NR9106; GA AV ČR IAA500200620
Institutional research plan: CEZ:AV0Z50200510
Keywords : Rheumatoid arthritis * NK cells * CD161
Subject RIV: EC - Immunology
Impact factor: 3.932, year: 2010
High levels of CD161 receptor of NK cells are correlated with impairment of NK cytotoxic activity in RA patients. We propose that MCV plays an important role in RA by increasing expression of CD161, which leads to inhibition of NK cell activity and, consequently, insufficient downregulation of autoreactive T cell, thus accelerating disease progression
Permanent Link: http://hdl.handle.net/11104/0190392
Number of the records: 1