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Glycosylation regulates NK cell-mediated effector function through PI3K pathway
- 1.0350365 - MBÚ 2011 RIV GB eng J - Journal Article
Benson, Veronika - Grobárová, Valeria - Richter, Jan - Fišerová, Anna
Glycosylation regulates NK cell-mediated effector function through PI3K pathway.
International Immunology. Roč. 22, č. 3 (2010), s. 167-177. ISSN 0953-8178. E-ISSN 1460-2377
R&D Projects: GA AV ČR IAA500200620; GA AV ČR IAA500200509; GA ČR GA204/06/0771; GA ČR GD310/08/H077
Institutional research plan: CEZ:AV0Z50200510
Keywords : cytotoxic activity * gene regulation * glycoconjugate
Subject RIV: EC - Immunology
Impact factor: 3.301, year: 2010
The modulation of glycosyltransferases MGAT3 and MGAT5 by chemically defined synthetic GCGN4C correlated with the improvement of NK cell effector functions and the augmentation of tumor cell sensitivity to NK cell-mediated cytotoxicity. These results demostrate the great potential of the GN4C compound as a NK cell-mediated antitumor response modulator
Permanent Link: http://hdl.handle.net/11104/0190384
Number of the records: 1