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Immunogenicity and immunomodulatory properties of HPMA-based polymers
- 1.0350356 - MBÚ 2011 RIV NL eng J - Journal Article
Říhová, Blanka - Kovář, Marek
Immunogenicity and immunomodulatory properties of HPMA-based polymers.
Advanced Drug Delivery Reviews. Roč. 62, č. 2 (2010), s. 184-191. ISSN 0169-409X. E-ISSN 1872-8294
R&D Projects: GA AV ČR KAN200200651; GA AV ČR IAAX00500803; GA AV ČR IAA500200712; GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z50200510
Keywords : Immunogenicity * Hpma * Immunomodulation
Subject RIV: EE - Microbiology, Virology
Impact factor: 13.577, year: 2010
In this study it was shown both in mice and humans that HPMA copolymer-bound doxorubicin (DOX-HPMA) conjugates possess besides powerfull anti-tumor effect also various immunomodulatory properties and exert significantly decreased side-toxicities, minimized bone marrow toxicity and cardiotoxicity being the most important ones. The possibility to induce potent and long-lasting tumor-specific immunity during the tratment with these compounds which is capable to provide protection against minimal residual disease is one of the most important and therapeutically valuable features of these conjugates
Permanent Link: http://hdl.handle.net/11104/0006133
Number of the records: 1