Calreticulin is a B cell molecular target in some gastrointestinal malignancies

0350328 - MBÚ 2011 RIV GB eng J - Journal Article
Pekáriková, Aneta - Sánchez, Daniel - Palová-Jelínková, Lenka - Šimšová, Marcela - Beneš, Z. - Hoffmanová, I. - Drastich, P. - Janatková, I. - Mothes, T. - Tlaskalová-Hogenová, Helena - Tučková, Ludmila
Calreticulin is a B cell molecular target in some gastrointestinal malignancies.
Clinical and Experimental Immunology. Roč. 160, č. 2 (2010), s. 215-222. ISSN 0009-9104. E-ISSN 1365-2249
R&D Projects: GA AV ČR IAA500200709; GA AV ČR IAA500200801; GA ČR GD310/08/H077; GA ČR GA310/07/0414; GA MŠMT 2B06155
Institutional research plan: CEZ:AV0Z50200510
Keywords : antigenic epitopes * autoantibodies * calreticulin
Subject RIV: EC - Immunology
Impact factor: 3.134, year: 2010

Using enzyme-linked immunosorbent assay (ELISA) , we found immunoglobulin (Ig)A and/or IgG anti-calreticulin antibodies in sera of approximately 63 of patients with hepatocellular carcinoma, 57 of patients with colorectal adenocarcinoma (CRA) and 47% of patients with pancreatic adenocarcinoma (PACA), while healthy controls, patients with viral hepatitis C and with chronic pancreatitis reached only 2, 20 abd 31 seropositivity, respectively. Pepscan analysis revealed a large number of antigenic epitopes of calreticulin recognized by both IgA and IgG antibodies of patients with HCC and PACA, indicating robust systemic immune response
Permanent Link: http://hdl.handle.net/11104/0190357