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A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms

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    0350230 - MBÚ 2011 RIV GB eng J - Journal Article
    D'Antona, N. - Morrone, R. - Bovicelli, P. - Gambera, G. - Kubáč, David - Martínková, Ludmila
    A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms.
    Tetrahedron Asymmetry. Roč. 21, č. 20 (2010), s. 2448-2454. ISSN 0957-4166
    R&D Projects: GA MŠMT OC09046
    Institutional research plan: CEZ:AV0Z50200510
    Keywords : BETA-GLUCOSIDASE INHIBITOR * FACILE SYNTHESES * CYCLOPHELLITOL
    Subject RIV: CC - Organic Chemistry
    Impact factor: 2.484, year: 2010

    A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S,6S)-4,5,6-trihydroxycyclohex-2-enecarbonitrile by a cooperative use of lipase, nitrile hydratase, and amidase
    Permanent Link: http://hdl.handle.net/11104/0190283

     
     
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