Exposure to air pollution in critical prenatal time windows and IgE levels in newborns

0350213 - ÚEM 2013 RIV DK eng J - Journal Article
Herr, C.E.W. - Grosh, R. - Dostál, Miroslav - Skokanová, V. - Ashwood, P. - Lipsett, M. - Joad, J.P. - Pinkerton, K.E. - Yap, P.S. - Frost, J. D. - Šrám, Radim - Hertz-Picciotto, I.
Exposure to air pollution in critical prenatal time windows and IgE levels in newborns.
Pediatric Allergy and Immunology. Roč. 22, č. 1 (2011), s. 75-84. ISSN 0905-6157. E-ISSN 1399-3038
R&D Projects: GA MŽP(CZ) SP/1B3/8/08
Institutional research plan: CEZ:AV0Z50390512
Keywords : immunoglobulin * developmental immunology * pregnancy
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 2.459, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0350213_01.pdf

The association between elevated cord serum IgE levels and maternal air pollution exposure during each month of gestation was analyzed. Total cord serum IgE was determined by the CAP system and mother´s total IgE levels by nephelometry for 459 births (from Mar 1994 to Jan. 1997) in the Czech Rep. Conc. of PAHs and particulate matter (PM2,5) were measured in ambient air, and arithmetic means were calculated for each gestational month. Heterogeneity by maternal atopy status was evaluated for air pollutants and cigarette smoke. In was found that PAHs and PM2,5 constituents of both ambient air and cigarette smoke appear to influence fetal immune development, particularly among infants whose mothers are not atopic.
Permanent Link: http://hdl.handle.net/11104/0190273