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Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
- 1.0350189 - ÚEM 2011 RIV US eng J - Journal Article
Evans, M. D. - Olinski, R. - Loft, M. S. - Rössner ml., Pavel - Šrám, Radim … Total 43 authors
Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress.
FASEB Journal. Roč. 24, č. 4 (2010), s. 1249-1260. ISSN 0892-6638. E-ISSN 1530-6860
Institutional research plan: CEZ:AV0Z50390512
Keywords : DNA damage * DNA repair * immunoassay
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 6.515, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0350189_01.pdf
The manuscript compares chromatographic and immunoassay methods used for the detection of urinary 8-oxo-7,8-dihydro-2‘-deoxyguanosine (8-oxodG). Samples containing different concentrations of 8-oxodG were sent to ESCULA members. Data were returned from 17 laboratories, representing 20 detection methods. There was good within-technique agreement for most of the laboratories. ELISA, however, showed more within-technique variation and reported higher 8-oxodG values. Overall, the study reveals greater consensus than previously expected, although some concern remains over ELISA.
Permanent Link: http://hdl.handle.net/11104/0190256
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